Dr. Guy Sauvageau is the CEO, Scientific Co-Founder and the Chief Scientific Officer at ExCellThera. He is also the Principal Investigator of the Molecular Genetics of Stem Cells research unit at the Institute for Research in Immunology and Cancer (IRIC) of University of Montreal, where he was Scientific Director from 2003 to 2013 and CEO from 2007 to 2014. He also holds the Tier 1 Canada Research Chair in Molecular Genetics of Stem Cells and he is a Professor of the Faculty of Medicine at University of Montreal. His seminal contributions to the field of hematopoietic stem cell biology have been published in several high impact scientific journals and acknowledged by numerous awards. He currently leads a team of 30 researchers.
Dr. Sauvageau’s research program aims at understanding the basic mechanisms that regulate the activity of both normal hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), with the ultimate goal of applying this knowledge to control their survival, proliferation and differentiation in clinically-relevant situations. With his research team, he has characterized the function of several developmental genes in HSC and LSC self-renewal. He later developed genome-wide screening strategies that identified many novel regulators of HSC and LSC activity. More recently, his team and collaborators (Marinier, IRIC; Zandstra, Toronto; Humphries and Eaves, Vancouver; Kiem and Delaney, Seattle) identified a novel molecule that stimulates the expansion of human cord blood HSCs. Guy Sauvageau is also a clinician scientist at Maisonneuve-Rosemont Hospital (HMR), specialized in bone marrow transplantation, the Scientific Advisor of the Québec Leukemia Cell Bank, as well as a co-founder of the Center of Excellence for Cell Therapy at HMR.
Dr. Sauvageau graduated in Medicine with specialties in Internal Medicine and Hematology, and he holds a Master’s degree in Immunology and Virology from the Faculty of Medicine of University of Montreal, as well as a Ph.D. in Experimental Medicine at the Terry Fox Laboratory of the BC Cancer Research Centre.